Megalochori is a rock village (dug into the bed of a torrent) in the interior of the island that is known to have existed since at least the middle of the 17th century. A small place but a lively community with a fairly large permanent population. One of the most peaceful and traditional villages of Santorini, located about nine kilometers from Fira. The churches of Aghi Anargyri, Isodia tis Theotokou and Aghios Nikolaos Marmaritis on the road to Emborio are worth seeing.

During the grape harvest, Megalochori becomes a totally different place. Grapes are spread out on the terraces of the houses to be made into visanto or raisins, heavily laden baskets are carried back and forth, and in general the place is caught up in the frenzy of wine-making. Three of the island's wineries are located in Megalochori - Boutaris, Antoniou and Iliopoulos.
Aghios Nikolaos Marmaritis took the name Marmaritis because it is all made by marble-marmaro in Greek. The church kept its doric style of the fourth century untouched after it was converted to a Christian one. Megalohori hosts the most vineyards of the island and is a traditional settlement with vaulted houses and stone-cobbled streets.

Megalochori attracts a fair number of tourist, choose it as a handy base for exploring the island: it is not faraway from Fira, and within easy distance of Akrotiri and the beaches of the Southeastern coast. There are number of small hotels around the village and along the Caldera.